Initiation of meiotic recombination by formation of DNA double-strand breaks: mechanism and regulation.
نویسندگان
چکیده
Homologous recombination is essential for accurate chromosome segregation during meiosis in most sexual organisms. Meiotic recombination is initiated by the formation of DSBs (DNA double-strand breaks) made by the Spo11 protein. We review here recent findings pertaining to protein-protein interactions important for DSB formation, the mechanism of an early step in the processing of Spo11-generated DSBs, and regulation of DSB formation by protein kinases.
منابع مشابه
Mechanism and regulation of meiotic recombination initiation.
Meiotic recombination involves the formation and repair of programmed DNA double-strand breaks (DSBs) catalyzed by the conserved Spo11 protein. This review summarizes recent studies pertaining to the formation of meiotic DSBs, including the mechanism of DNA cleavage by Spo11, proteins required for break formation, and mechanisms that control the location, timing, and number of DSBs. Where appro...
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ورودعنوان ژورنال:
- Biochemical Society transactions
دوره 34 Pt 4 شماره
صفحات -
تاریخ انتشار 2006